Smad 2/3-luc

(Smad 2 and 3)

Application to wound healing and burn injury:
Can be used to monitor TGFb signaling and is a marker for scarring.  Shown to be up-regulated following cutaneous wound injury with a peak 1-3 days.

References (Selected applications):
1. Lin AH, Luo J, Mondshein LH, ten Dijke P, Vivien D, Contag CH, Wyss-Coray T. J Immunol. 2005 Jul 1;175(1):547-54

Pubmed link (15972691)

Background Strain:  FVB/N

TRANSGENIC REPORTER MODELS

VEGFR2-luc

NF-kB-luc

Smad 2/3-luc

GFAP-luc

NFAT5-luc