NF-kB-luc

(NF-kB response element)

Application to wound healing and burn injury:
Can be used to monitor inflammation from local or systemic insults.  Shown to be up-regulated in multiple organs within 48-72 hours.

References (Selected applications):
1. Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, Washington MK, Yull FE, Jaffal N, Jansen ED, Gautman S, Stain SC., J Surg Res. 2003 Mar;110(1):310-4

Pubmed link (12697416)

2. Sadikot RT, Wudel LJ, Jansen DE, Debelak JP, Yull FE, Christman JW, Blackwell TS, Chapman WC., J Gastrointest Surg. 2002 Mar-Apr;6(2):264-70

Pubmed link (11992813)

Background Strain:  FVB/N


TRANSGENIC REPORTER MODELS

VEGFR2-luc

NF-kB-luc

Smad 2/3-luc

GFAP-luc

NFAT5-luc